Table 4 Diagnostic accuracy of OCT angiography and spectral-domain OCT parameters.

From: Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography

 

AUC

95% CI

p value

Cutoff value

Sensitivity (%)

Specificity (%)

NMOSD + ON versus MS + ON

RPC (%)

Superior

0.726

(0.536 to 0.916)

0.020

38.6

44.4

96.7

Inferior

0.780

(0.611 to 0.948)

0.001

52.7

100

43.3

S/T ratio

0.778

(0.605 to 0.950)

0.002

0.86

44.4

100

I/N ratio

0.802

(0.627 to 0.977)

0.001

1.04

66.7

86.7

I/T ratio

0.833

(0.692 to 0.975)

 < 0.001

1.04

77.8

80.0

RNFL (μm)

Temporal

0.606

(0.385 to 0.938)

0.348

64

100

26.7

Inferior

0.631

(0.404 to 0.859)

0.258

74

33.3

96.7

NMOSD-ON versus MS-ON

RPC (%)

Temporal

0.692

(0.515 to 0.869)

0.034

51.6

63.6

73.3

S/T ratio

0.707

(0.561 to 0.853)

0.006

1.06

90.9

48.9

N/T ratio

0.728

(0.563 to 0.894)

0.007

0.92

72.7

68.9

  1. The optimal cutoff values were determined by Youden’s index.
  2. AUC Area under the curve, CI Confidence interval, I Inferior, MS Multiple sclerosis, N Nasal, NMOSD Neuromyelitis optica spectrum disorder, OCT Optical coherence tomography, ON Optic neuritis, RNFL Retinal nerve fiber layer, RPC Radial peripapillary capillaries, S Superior, T Temporal.
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