Figure 1

(a) Mean cognitive score at age four corrected for sex and SES by Schizophrenia GPS and gestational age for individuals falling in the highest and lowest 20% of the distribution of Schizophrenia GPS. There was evidence for an interaction effect (F(1506) = 8.03, p = 4.65 × 10–3); (b) Mean cognitive score at age 4 corrected for sex and SES by Bipolar disorder GPS and gestational age for individuals falling in the highest and lowest 20% of the distribution of the Bipolar Disorder GPS. No statistically significant interaction effect was found (F(1530) = 1.55 P = 0.213), GPS: genome-wide polygenic score.