Figure 5
Organoid OCIP256 with KRASwt and putative actionable BRAF had activated phospho-ERK (pERK) and phospho-AKT (pAKT). (A) Levels of pERK decreased with either LY3009120 (LY) and/or trametinib (Tram) treatments. Original scanned films are shown in Supplementary Fig. S8. (B) Inhibition of XDO tumor cell growth was measured with drug treatments, LY3009120 (10–0.001 uM), trametinib (1.25–0.0001 uM), or combined LY:Tram at 8:1ratio. (C) Drug sensitivities were evaluated in its parent PDX model.
