Table 3 Regions-of-interest (ROI) measures by age-matched male group comparisons.

From: Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition

 

PRE

MALEPRE

PERI

MALEPERI

POST

MALEPOST

ATP/PCr measures

Anterior cingulate cortex

1.06 (0.07)

1.11 (0.07)

1.10 (0.04)

1.12 (0.05)

1.12 (0.04)

1.12 (0.05)

Adjusted by APOE-4 status

1.05 (0.07)

1.12 (0.07)

1.11 (0.04)

1.10 (0.05)

1.11 (0.04)

1.13 (0.05)

Insula

1.21 (0.06)

1.29 (0.07)

1.24 (0.04)

1.24 (0.04)

1.26 (0.03)*

1.21 (0.05)

Adjusted by APOE-4 status

1.20 (0.06)

1.30 (0.06)

1.24 (0.04)

1.23 (0.04)

1.27 (0.03)*

1.22 (0.05)

Inferior parietal lobule

0.78 (0.07)

0.85 (0.08)

0.76 (0.04)

0.84 (0.04)

0.83 (0.03)

0.86 (0.04)

Adjusted by APOE-4 status

0.77 (0.08)

0.86 (0.08)

0.76 (0.04)

0.84 (0.04)

0.83 (0.03)

0.86 (0.04)

Middle temporal gyrus

1.10 (0.04)

1.17 (0.05)

1.15 (0.02)

1.12 (0.3)

1.19 (0.02)*

1.10 (0.03)

Adjusted by APOE-4 status

1.10 (0.04)

1.18 (0.04)

1.15 (0.02)

1.12 (0.3)

1.19 (0.02)*

1.10 (0.03)

Medial temporal lobe

1.16 (0.05)

1.24 (0.05)

1.22 (0.03)

1.20 (0.04)

1.21 (0.03)

1.19 (0.04)

Adjusted by APOE-4 status

1.15 (0.05)

1.26 (0.05)

1.22 (0.03)

1.20 (0.04)

1.22 (0.03)

1.19 (0.04)

Medial frontal gyrus

1.05 (0.06)

0.99 (0.06)

1.04 (0.03)

0.98 (0.04)

1.07 (0.03)*

0.95 (0.04)

Adjusted by APOE-4 status

1.04 (0.06)

1.01 (0.06)

1.05 (0.03)

0.97 (0.04)

1.07 (0.03)*

0.96 (0.04)

Superior frontal gyrus

0.95 (0.05)

0.86 (0.06)

0.94 (0.03)*

0.84 (0.03)

0.96 (0.03)*

0.83 (0.04)

Adjusted by APOE-4 status

0.94 (0.05)

0.87 (0.05)

0.95 (0.03)*

0.84 (0.04)

0.96 (0.03)*

0.84 (0.04)

Amyloid-β load

AD-mask SUVR

1.01 (0.05)

0.92 (0.05)

1.20 (0.05)*

0.92 (0.06)

1.29 (0.05)*

0.93 (0.06)

Adjusted by APOE-4 status

1.01 (0.05)

0.92 (0.05)

1.21 (0.05)*

0.91 (0.06)

1.29 (0.05)*

0.93 (0.06)

AD-mask SUVR by APOE-4 status

APOE-4−

0.94 (0.07)

0.86 (0.07)

1.14 (0.06)

0.88 (0.08)

1.32 (0.07)*

0.93 (0.09)

APOE-4+

1.07 (0.07)

0.96 (0.08)

1.32 (0.09)*

0.93 (0.10)

1.25 (0.05)*

0.95 (0.10)

  1. MALEPRE, males age-matched to PRE; MALEPERI, males age-matched to PERI; MALEPOST, males age-matched to POST; PERI, peri-menopausal group; POST, post-menopausal group; PRE, pre-menopausal group.
  2. Values are means (SE).
  3. *Different from age-matched males, p < 0.05.
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