Figure 5

Cardiac remodeling in a histological follow-up regarding the scar-components elastin, collagen, monocyte-occurrence and blood supply. Figure AA1 shows the Graph of elastin occurrence 7 days after permanent ligation in wild type mice, CCR2-KO mice, CX3CR1and MCP1-KO mice. Figure A1 exhibits its corresponding exemplary histological image with Elastica-van Giesson-staining. Figure AA2 represents the graph of collagen deposit 7 days after permanent ligation in wild type mice, CCR2-KO mice, CX3CR1 and MCP1-KO mice and figure A2 represents the corresponding exemplary histological image with Picrosirius red staining. Figure AA3 indicates the graph of scar formation 7 days after permanent ligation in wild type mice, CCR2-KO mice, CX3CR1 and MCP1-KO mice and figure A3 exhibits the corresponding exemplary histological image with the aid of Masson’s Trichrome staining. Figure AA4 exhibits inflammation in graphic formation 7 days after permanent ligation in wild type mice, CCR2-KO mice, CX3CR1 and MCP1-KO mice and figure A4 its corresponding exemplary histological image with F4/80 staining. Figure AA5 shows the occurrence of new vessel formation in graphical order 7 days after permanent ligation in wild type mice, CCR2-KO mice, CX3CR1 and MCP1-KO mice and A5 its corresponding exemplary histological image with alpha smooth vessel staining. Figure BA1 points out the Graph of elastin occurrence 30 days after permanent ligation in wild type mice, CCR2-KO mice, CX3CR1 and MCP1-KO mice. Figure B1 exhibits its corresponding exemplary histological image with the aid of Elastica-van-Giesson staining. Figure BA2 represents the graph of collagen deposit 30 days after permanent ligation in wild type mice, CCR2-KO mice, CX3CR1 and MCP1-KO mice and figure B2 represents the corresponding exemplary histological image with Picrosirius red staining. Figure BA3 indicates the graph of scar formation 30 days after permanent ligation in wild type mice, CCR2-KO mice, CX3CR1and MCP1-KO mice and figure B3 exhibits the corresponding exemplary histological image with the aid of Masson’s Trichrome staining. Figure BA4 exhibits inflammation in graphic formation 30 days after permanent ligation in wild type mice, CCR2-KO mice, CX3CR1and MCP1-KO mice and figure B4 its corresponding exemplary histological image with F4/80 staining. Figure BA5 shows the occurrence of new vessel formation in graphical order 30 days after permanent ligation in wild type mice, CCR2-KO mice, CX3CR1and MCP1-KO mice and B5 its corresponding exemplary histological image with alpha smooth vessel staining.