Figure 3
From: Prematurity alters the progenitor cell program of the upper respiratory tract of neonates
Prematurity is associated with a distinctive gene expression signature in NP-derived basal cells. (a) Dot plots of top 10 enriched GO terms based on overrepresented p-value generated by goseq in undifferentiated confluent cultures of preterm vs term NP basal cells. Dot size represents the number of genes from a particular GO term differentially expressed (count), color depicts the p-value, and hit (%) refers to the percentage of differentially expressed genes in a GO term. (b) Ridge plots of all significantly enriched pathways by GSEA analysis (p-adjusted value < 0.05) in these cultures. (c) Heat map depicting gene expression signatures of each preterm and term samples (confluent basal cells before differentiation). (d) Volcano plot highlighting the fold change and significance of the most differentially expressed genes Significantly regulated genes above and below twofold are shown in red and blue, respectively.
