Figure 6
Modified from Dubielecka et al.21.
Schematic comparison of the exons and functional domains of ABI1-TSV-11 and the full-length ABI1 (ABI1-TSV-1/isoform a). (a) ABI1-TSV-11 has conserved WAVE2-binding and SH3 domains, but lacks the homeo-domain homologous region (HHR) and a majority of the PxxP- and Pro-rich domain. E: exon, pY213/421/435/506: phosphorylation at tyrosine 213/421/435/506, pSer216: phosphorylation at serine 216. WAVE-BD: WASP family verprolin-homologous protein-binding domain, HHR: homeodomain homologous region, Abl-SH3-SH2: Abl-Src homology 3-Src homology 2, Ser-rich: Serine-rich, SH3: Src homology 3.
