Figure 3 | Scientific Reports

Figure 3

From: Inhibitory synaptic transmission is impaired at higher extracellular Ca2+ concentrations in Scn1a+/− mouse model of Dravet syndrome

Figure 3

Changes in the inhibitory synaptic transmission of Scn1a+/− neurons. (a) Representative traces of evoked inhibitory postsynaptic currents (IPSCs) recorded from a single autaptic hippocampal neuron of either wild-type (WT) or Scn1a+/− mice. Depolarization artifacts caused by the generated action currents have been removed for clarity of presentation. (b) Average amplitudes of the evoked IPSCs in neurons of WT or Scn1a+/− mice (WT: 7.94 ± 0.55 nA, n = 96; Scn1a+/−: 6.18 ± 0.42 nA, n = 98/N = 5 cultures, *p < 0.05). (c) Representative miniature IPSC (mIPSC) traces in neurons of either WT or Scn1a+/− mice. (d) Average mIPSC amplitudes in neurons of either WT or Scn1a+/− mice (WT: 26.94 ± 0.80 pA, n = 95; Scn1a+/−: 26.70 ± 0.86 pA, n = 96/N = 5 cultures). (e) Average mIPSC frequencies in neurons of either WT or Scn1a+/− mice (WT: 1.85 ± 0.25 Hz, n = 95; Scn1a+/−: 1.50 ± 0.21 Hz, n = 96/N = 5 cultures). Data were obtained from the same autaptic neurons as in (d).

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