Figure 4
Identification of suitable targets for combination therapy by comparing subgraphs within the COVID-19 PHARMACOME. Incorporation of gene expression data into the COVID-19 PHARMACOME resulted in a subgraph characterized by the entities (genes/proteins) that respond to viral infection (a). Mapping of the filtered results obtained from drug repurposing screenings (IC50 < 10 µM) to the PHARMACOME resulted in a subgraph enriched for drug repurposing targets (b). The intersection between subgraphs presented in (a, b) is highly enriched for drug repurposing targets directly linked to the viral infection response (c).
