Table 2 Most highly up- or downregulated retinal transcripts in bTBI- versus sham-treated mice at 1-week post injury detected by RNA sequencing.
From: Axonopathy precedes cell death in ocular damage mediated by blast exposure
Symbol | Transcript | Fold change | p-value | FDR |
|---|---|---|---|---|
Upregulated | ||||
Mmp12 | Matrix metallopeptidase 12 | 27.83 | 2.48E−10 | 3.70E−06 |
Ecel1 | Endothelin converting enzyme-like 1/DINE | 14.60 | 3.11E−08 | 6.76E−05 |
6430562O15Rik | Long non-coding RNA | 2.03 | 2.88E−08 | 6.76E−05 |
Oasl2 | 2′–5′ Oligoadenylate synthetase-like 2 | 4.23 | 2.91E−08 | 6.76E−05 |
Isg15 | ISG15 ubiquitin-like modifier | 3.82 | 3.17E−08 | 6.76E−05 |
Gbp2 | Guanylate binding protein 2 | 3.80 | 1.89E−08 | 6.76E−05 |
Ptgfr | Prostaglandin F receptor | 4.30 | 1.08E−07 | 0.00018 |
Irf9 | Interferon regulatory factor 9 | 2.80 | 1.01E−07 | 0.00018 |
Cd180 | CD180 antigen | 6.21 | 1.30E−07 | 0.00019 |
Psmb8 | Proteasome (prosome, macropain) subunit, beta type 8 | 2.65 | 1.51E−07 | 0.00019 |
Downregulated | ||||
Limk1 | LIM-domain containing, protein kinase | 0.63 | 3.05E−08 | 6.76E−05 |
Lynx1 | Ly6/neurotoxin 1 | 0.72 | 2.60E−07 | 0.0002 |
Dlgap3 | DLG associated protein 3 | 0.74 | 4.81E−07 | 0.00026 |
Tubb3 | Tubulin, beta 3 class III | 0.73 | 5.15E−07 | 0.00026 |
Cend1 | Cell cycle exit and neuronal differentiation 1 | 0.67 | 5.04E−07 | 0.00026 |
Kcnip4 | Potassium voltage-gated channel interacting protein 4 | 0.65 | 6.54E−07 | 0.00029 |
Nat8l | N-Acetyltransferase 8-like | 0.71 | 9.74E−07 | 0.00035 |
Apba1 | Amyloid beta (A4) precursor protein binding, family A, member 1 | 0.76 | 1.05E−06 | 0.00035 |
Nefm | Neurofilament, medium polypeptide | 0.61 | 1.23E−06 | 0.00036 |
