Table 2 Histological evaluation of hearts and pancreata in saline, wt CVB3, Mt 10-infected, and Mt 10-infected and challenged mice.

From: Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis

Parameters

Saline

wt CVB3

Mt 10

Mt 10 + wt CVB3

Heart

Incidence

0/9 (0.0)

12/18 (66.7)

0/16 (0.0)

0/17 (0.0)

Mortality

0/9 (0.0)

9/18 (50)

0/16 (0.0)

0/17 (0.0)

Myocardial lesions

0.0 (0.0)a

34.5 ± 13.3

0.0 (0.0)a

0.0 (0.0)a

Pancreas

Incidence

0 (0.0)

16/18 (88.9)

1/16 (6.2)

0 (0.0)

Atrophy

0 (0.0)a

16/18 (88.9)

1/16 (6.2)a

0 (0.0)a

Inflammation

0 (0.0)a

16/18 (88.9)

0/16 (0.0)a

0 (0.0)a

Necrosis

0 (0.0)

0/18 (0.0)

0/16 (0.0)

0 (0.0)

Mineralization

0 (0.0)

0/18 (0.0)

0/16 (0.0)

0 (0.0)

  1. () Indicates percentages.
  2. aDenotes significant differences in comparison with wt CVB3 group (p < 0.0001).