Figure 1 | Scientific Reports

Figure 1

From: Identification of BHLHE40 expression in peripheral blood mononuclear cells as a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma

Figure 1

Transcriptome profiling of cancer-induce genes and integration transcription profiles of PBMCs. (A) volcano plot presents differentially expressed genes in PBMCs compared with healthy controls. (B) Volcano plot presents differentially expressed genes in PBMCs of co-culture compared with control. Volcano plot shows − log10P-values on the y-axis and fold change expressed as log2 on the x-axis. Red scatter dots represent up-regulated genes with P ≤ 0.05 and log2fold change ≥ 1.5. Blue scatter dots represent down with P ≤ 0.05 and log2fold change ≤ -1.5. Green scatter dots represent a candidate of cancer-induced genes for validation in PBMCs. (C) Venn diagram represents intersect genes between 3 transcription profiles of PBMCs including PBMCs from patients with HCC, PBMCs from co-culture model and published microarray data. (D) Heatmap of cancer-induced genes expression in PBMCs of patients with HCC. Candidate of cancer-induced genes for validation are labels in green.

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