Table 2 Variables associated with overall survival in patients with HCC.

Age (years)

 < 60 vs. ≥ 60

1.02 (0.67–1.55)

0.924

Gender

Male vs. Female

1.16 (0.66–2.08)

0.608

Total bilirubin (mg/dL)

 < 1.2 vs. ≥ 1.2

0.77 (0.49–1.27)

0.303

Serum albumin (g/dL)

 < 3.5 vs. ≥ 3.5

1.02 (0.63–1.65)

0.946

Aspartate aminotransferase (IU/L)

 < 60 vs. ≥ 60

1.62 (1.06–2.49)

0.027*

1.34 (0.83–2.16)

0.230

Alanine aminotransferase (IU/L)

 < 50 vs. ≥ 50

1.63 (1.04–2.53)

0.032*

1.18 (0.73–1.92)

0.493

Platelet count (10⁹/L)

 ≥ 100 vs. < 100

1.43 (0.85–2.40)

0.178

Presence of cirrhosis

No vs. Yes

0.97 (0.58–1.64)

0.907

Alpha fetoprotein (ng/mL)

 < 100 vs. ≥ 100

1.93 (1.22–3.05)

0.005*

1.46 (0.88–2.42)

0.146

Tumor size (cm)

 < 5.0 vs. ≥ 5.0

1.53 (1.01–2.32)

0.043*

1.09 (0.63–1.90)

0.757

BCLC stage

0-A vs. B vs. C

1.94 (1.33–2.83)

0.001*

2.00 (1.22–3.27)

0.006*

BHLHE40

 < 1.8 vs. ≥ 1.8

3.21 (1.59–6.48)

0.001*

3.54 (1.52–8.34)

0.004*

DDIT4

 < 2.1 vs. ≥ 2.1

2.29 (1.35–3.91)

0.002*

0.94 (0.48–1.82)

0.850