Figure 5
From: Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection
The COVID-19-perturbed network analysis. (A) The histograms of \(\Delta \)ECv for the biopsy dataset. The X-axis corresponds to the threshold for the \(\Delta \)ECv. The Y-axis stands for the number of edges with log scale. (B) The COVID-19-perturbed network is shown. The network is composed of 127 nodes and 412 edges (including 245 basal edges). The colored solid edges represent DREs perturbed by COVID-19 (yellow). The dotted edges represent the basal edges (gray). The nodes (green) represent the known drug target genes (Supplementary Table S2). The node size represents the extent of outdegree. (C) The top 10 terms of canonical pathway analysis for the genes in the COVID-19-perturbed network. (D) The Venn diagram shows the numbers of the \(\Delta \)ECv-extracted DREs (\(\Delta \)ECv threshold 2.3) induced by COVID-19 perturbation for the biopsy dataset (yellow) overlapped with the two DREs through the Venn diagram analysis in Fig. 2B.
