Figure 6
From: Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection
Establishment of the COVID-19 patient-specific individual network. (A) The COVID-19 patient-specific network with RCs represented by edge sizes. The network comprises 127 nodes and 412 edges (including 245 basal edges). The colored solid edges represent DREs; SARS-CoV-2 (high MOI: 2) \(\cap \) COVID-19-perturbed (magenta), SARS-CoV-2 (low MOI: 0.2) \(\cap \) COVID-19-perturbed (blue), SARS-CoV-2 (high MOI: 2) \(\cap \) SARS-CoV-2 (low MOI: 0.2) \(\cap \) COVID-19-perturbed (purple), COVID-19-perturbed exclusive edges (yellow). The dotted edges represent the basal edges (gray). The nodes (green) represents the known drug target genes (Supplementary Table S2). The node size stands for the extent of outdegree. (B) Zoomed regions indicated in Fig. 6A for three individuals (healthy 1, healthy 2, and the patient with COVID-19). RCs are represented as edge sizes to show individual differences.
