Figure 4

Relationship between source TMS-EEG signal and DWI pathway projection. (A) Percentage of grey matter voxels (divided by network) reached by seed-based tractography from the stimulation spot. As for angular gyrus (DMN stimulation seed), the white matter fibers not only reach cortical regions belonging to the DMN (34.52%) but also affect the other RSNs (VISN = 6.52%; SMN = 13.95%; DAN = 17.55%; ASN = 10.72%; LIMN = 0.04%; FPN = 16.71%). Likewise for the superior parietal lobule (DAN stimulation spot), the seed-based tractography do not involve grey matter voxels belonging to DAN (41.38%), but also reach the other RSNs (VISN = 2.00%; SMN = 20.42%; ASN = 9.98%; LIMN = 0.01%; FPN = 11.77%; DMN = 14.45%). (B) A significant positive correlation was found between the number of voxels reached by the seed-based tractography (divided by network) and the AUC extracted for both DAN (visit 1: R² = 51%, p = 0.0003; visit 2: R² = 37%, p = 0.003) and DMN (visit 1: R² = 31%, p = 0.008; visit 2: R² = 29%, p = 0.01). (C) A significant positive correlation was found between the number of networks nodes (normalized for the overall number of network nodes) reached by the seed-based tractography and the AUC extracted for both DAN (visit 1: R² = 82%, p = 0.000000004; visit 2: R² = 66%, p = 0.000005) and DMN (visit 1: R² = 58%, p = 0.00003; visit 2: R² = 58%, p = 0.00003). Scatterplots were generated using R software (https://www.R-project.org/) ⁴⁴ version 1.1.453.