Table 2 Allelic, genotypic distribution and logistic regression analysis of significant variants of genes in our study.
From: Genetic evaluation of the variants using MassARRAY in non-small cell lung cancer among North Indians
Variant | rs12190287 | rs751402 | rs4986764 | rs2298881 | rs4757151 | rs11615 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene W.R.T variant | TCF21 | ERCC5 | BRIP1 | ERCC1 | ARNTL | ERCC1 | ||||||
Polymorphism | C/G | A/G | A/G | C/A | A/G | A/G | ||||||
Allele distribution | G | C | A | G | A | G | A | C | G | A | G | A |
Cases | 0.532 | 0.468 | 0.329 | 0.671 | 0.455 | 0.545 | 0.215 | 0.785 | 0.504 | 0.496 | 0.453 | 0.547 |
Controls | 0.648 | 0.352 | 0.268 | 0.732 | 0.546 | 0.454 | 0.289 | 0.711 | 0.584 | 0.416 | 0.531 | 0.469 |
Odds ratio at 95% CI | 1.62 (1.26–2.09) | 1.34 (1.02–1.75) | 1.44 (1.11–1.86) | 0.67 (0.49–0.90) | 1.38 (1.06–1.80) | 1.36 (1.03–1.80) | ||||||
Total HWE | 0.174 | 0.829 | 0.931 | 0.709 | 0.429 | 0.839 | ||||||
Genotypic model | Dominant (CC + GC vs GG) | Dominant AA + AG vs GG) | Additive (GG vs AG vs AA) | Additive (AA vs AC vs CC) | Recessive (AA vs AG + GG) | Recessive (AA vs AG + GG) | ||||||
Odds ratio at 95% CI | 1.85 (1.14–2.99) | 1.46 (1.00–2.13) | 1.47 (1.12–1.94) | 0.66 (0.48–0.91) | 2.12 (1.32–3.47) | 1.96 (1.23–3.11) | ||||||
p value* | 0.012 | 0.027 | 0.006 | 0.012 | 0.002 | 0.006 | ||||||
