Figure 3
Lymphocyte subset absolute counts in the five groups of patients stratified according to maximal oxygen supply/ventilation support. Absolute counts of total T-lymphocytes (CD3+, (A) and related subsets (CD3 + CD4+, (B) CD3 + CD8+, (C) CD3 + CD4 + CD8 + DP, (D) CD3 + CD4 − CD8 − DN, (E) CD4/CD8 ratio (F) B-lymphocytes (CD19+, (G) and NK-cells (CD3negCD16 + CD56+, (H) in the study population after stratification according to maximal oxygen supply/ventilation support required during hospitalization. Differences were analyzed using the Kruskal–Wallis and Dunn’s multiple comparison tests; the AA group was used as a reference group for multiple comparisons. Patients were further grouped into nonsevere (AA and VMK, blue dashed line box) and severe (NRM, NIV and OTI, red dashed line box); differences were analyzed using the Mann–Whitney test. A two-sided p value of < 0.05 was considered statistically significant. AA ambient air, VMK Venturi mask, NRM nonrebreather oxygen mask with concentrator, NIV noninvasive mechanical ventilation, OTI Orotracheal Intubation for mechanical ventilation. *0.01 < p < 0.5; **0.001 < p < 0.01; ***0.0001 < p < 0.00001; ****p < 0.0001.
