Table 2 Arterial blood gas (ABG) values in 15-min intervals after the start of the trial intervention.

From: Therapeutic hypercapnia for prevention of secondary ischemia after severe subarachnoid hemorrhage: physiological responses to continuous hypercapnia

 

PaCO2

pH

PaO2

Baseline

38.75 ± 3.65

7.44 ± 0.04

112.6 ± 24.0

Hyp 0 min

47.15 ± 4.81

7.34 ± 0.36

109.8 ± 15.8

Hyp 15 min

50.30 ± 5.02

7.31 ± 0.39

110.7 ± 17.0

Hyp 30 min

52.42 ± 4.13

7.30 ± 0.39

110.3 ± 14.5

Hyp 45 min

53.76 ± 5.17

7.29 ± 0.37

110.6 ± 14.2

Hyp 60 min

54.22 ± 5.27

7.29 ± 0.38

111.9 ± 14.0

Hyp 75 min

54.25 ± 5.06

7.28 ± 0.38

112.2 ± 16.8

Hyp 90 min

54.01 ± 5.51

7.29 ± 0.38

112.3 ± 12.4

Hyp 105 min

54.37 ± 4.66

7.29 ± 0.38

111.4 ± 12.2

Hyp 120 min

53.18 ± 7.16

7.29 ± 0.38

111.7 ± 13.7

  1. After measurement of the baseline value, the respiratory minute volume (RMV) was reduced. The first ABG analysis after reducing the RMV was taken 5 min thereafter to exclude an exaggerated individual effect of the reduction of RMV. “Hyp 0 min” indicates a timepoint 15 min after the start of the study intervention and reduction of RMV. This value was then used to further modify the RMV to reach a target of 55 mmHg. (PaCO2 = arterial partial pressure of carbon dioxide, PaO2 = arterial partial pressure of oxygen, Hyp + # min indicates the time after the start of the hypercapnic trial intervention).
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