Figure 4
Latent variables. This figure takes the latent variable plots from Fig. 2 and supplements them with those that will appear in Figs. 5, 6 and 7, standardising the y-axes for ease of comparison. The format is as described in Fig. 2. We will unpack the details of these plots as they are introduced in subsequent figures. However, the highlights are (1) the attenuation of peak viral load in the second to fourth row of plots, relative to the first row, (2) the smaller antibody response required to suppress the infection in the second and fourth rows of plots, (3) the earlier peak in IgG plasma cells and antibodies in the third row of plots. The key message from this figure is that there are several different dimensions along which immune responses may vary, with consequences for viral suppression.
