Figure 5
Attenuating viral entry into cells. This figure uses the same layout as Fig. 2. Here, the proportion of extracellular virus entering the intracellular compartment per hour has been decreased, remembering that the production of extracellular virus depends upon there being intracellular virus that can use the cellular machinery to manufacture and secrete new virus particles. Decreasing the rate of cell entry therefore slows the growth of the viral population, leading to a smaller peak with a smaller immune response required to suppress the infection. Note the decrease in antibody titre, which might mean that people exhibiting this immune phenotype may not have detectable antibodies in serological testing post-infection.
