Figure 1 | Scientific Reports

Figure 1

From: Systems biology approach highlights mechanistic differences between Crohn’s disease and ulcerative colitis

Figure 1

Node scoring with transcriptomic data. In addition to the backbone layer, which describes the molecular pathways involved in each biological process, the network models have a second layer, which harbours information about mRNA regulated by some of the entities in the model backbone (inset above). The activity of the nodes in the model backbone is inferred on the basis of the concordance of transcriptomic changes in the data with the mRNA nodes underneath the backbone nodes. The figure was created using Cytoscape v3.7.1 (https://cytoscape.org). The Cytoscape graph was then exported to pdf and the layout was further modified for better readability in Adobe Illustrator 2019 (https://adobe.com).

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