Table 2 The most connected nodes.

From: Systems biology approach highlights mechanistic differences between Crohn’s disease and ulcerative colitis

Node name

Barrier defense

bp(PMIBP:"tight junction disruption")

complex(GOCC:"NF-kappaB complex")

act(p(SFAM:"TNFRSF Family"))

bp(PMIBP:"Intestinal permeability")

bp(GOBP:"programmed cell death")

p(HGNC:OCLN)

complex(SCOMP:"Interferon Gamma Receptor Complex")

act(p(HGNC:MYLK))

act(p(HGNC:VDR))

act(p(SFAM:"MAPK JNK Family"))

Inflammation

path(MESHD:Inflammation)

complex(GOCC:"NF-kappaB complex")

complex(GOCC:"interleukin-1 receptor complex")

act(p(HGNC:MEFV))

act(p(HGNC:MYD88))

act(p(HGNC:STAT3))

act(p(HGNC:NOD2))

act(p(HGNC:MMP19))

act(p(HGNC:PPARG))

p(HGNC:IL6)

Wound healing

bp(GOBP:"cell proliferation")

bp(GOBP:"epithelial cell migration")

bp(GOBP:"wound healing")

complex(GOCC:"NF-kappaB complex")

act(p(HGNC:CTNNB1))

act(p(HGNC:CRHR2))

act(p(SFAM:"TNFRSF Family"))

complex(PMICOMP:"FGF receptor complex")

act(p(HGNC:MMP9))

act(p(HGNC:STAT3))