Table 2 KEGG pathway and Cellular processes analysis of Hub genes implicated in EOCRC progression on STRING database. (A) Cellular process analysis of Hub genes on string database. (B) KEGG pathway analysis of Hub genes on string database.
(A) | GO-term | Description | Count in gene set | False discovery rate |
|---|---|---|---|---|
1 | GO:0005899 | Insulin receptor complex | 2 of 2 | 0.00048 |
2 | GO:0009986 | Cell surface | 6 of 690 | 0.00099 |
3 | GO:0009897 | External side of plasma membrane | 4 of 223 | 0.00099 |
4 | GO:0005887 | Integral component of plasma membrane | 8 of 1564 | 0.00099 |
5 | GO:0098802 | Plasma membrane receptor complex | 3 of 158 | 0.0065 |
(B) | Pathway | Description | Count in gene set | False discovery rate |
|---|---|---|---|---|
1 | hsa04060 | Cytokine–cytokine receptor interaction | 7 of 263 | 1.23e−07 |
2 | hsa04640 | Hematopoietic cell lineage | 5 of 94 | 7.12e−07 |
3 | hsa04010 | MAPK signaling pathway | 6 of 293 | 3.50e−06 |
4 | hsa04151 | PI3K-Akt signaling pathway | 5 of 348 | 0.00016 |
5 | hsa04014 | Ras signaling pathway | 4 of 228 | 0.00036 |
