Figure 1

Rendering of three-dimensional image of BA22 cerebral tissue of schizophrenia case S1 and Cartesian-coordinate model of its vessel network. The pial surface is toward the top. (A) Three-dimensional image of the tissue. Linear attenuation coefficients of 8–50 cm⁻¹ were rendered in gray scale with the maximum projection method of the VG Studio software. Scale bar: 100 μm. (B) Cartesian-coordinate model of vessel network built by tracing the three-dimensional image. The model is viewed from nearly the same direction as the rendering. The vessel models of the other 23 samples were built in the same manner (Supplementary Figures S1–S17). The model was drawn with the MCTrace software. Model constituents are color-coded. The vessels magnified in panels C–E are indicated with boxes. (C–E) Cartesian-coordinate models of capillary vessels (red) superposed on cage representations of the three-dimensional image (gray) contoured at 6 times the standard deviation of the image from its mean intensity. Blood cells were visualized in the vessel lumen as low-intensity bodies. Positions of these vessels are indicated with boxes in (B). Scale bar: 10 μm.