Figure 6 | Scientific Reports

Figure 6

From: Random survival forests identify pathways with polymorphisms predictive of survival in KRAS mutant and KRAS wild-type metastatic colorectal cancer patients

Figure 6

Kaplan–Meier curves and log-rank test for TAM pathway SNPs predictive of PFS and OS in KRAS wild-type and mutant mCRC patients: (A) KRAS wildtype patients with TBK1 rs7486100 A/A variant have longer PFS (11.3 vs. 10.3 mo; p = 0.020) and (B) OS (31.3 vs. 24.8 mo; p = 0.040) compared to those with Any T allele. (C) KRAS mutant patients with TBK1 rs7486100 A/A genotype also have longer PFS (10.3 vs. 8.6 mo; p = 0.005). (D) TAM pathway SNP CCL2 rs4586 T/T carriers have longer OS (30.9 vs. 22.8 mo; p = 0.006).

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