Table 2 The percent inhibition (interquartile range [IQR]) of area under the curve (AU*min), maximum aggregation (AU), and aggregation velocity (AUC/min), measured by whole blood aggregometry, in cats with the wildtype (WT) and the variant genotype (both homozygous and heterozygous) in various genotypes (P2RY1:A236G, P2RY12:V34I, and CYP2C41:H231R).
Genotype | Nucleotide | AUC (AU*min) (IQR) | P value (overall) | P value | Maximum aggregation(AU) (IQR) | P value (overall) | P value | Aggregation velocity (AU/min) (IQR) | P value (overall) |
|---|---|---|---|---|---|---|---|---|---|
P2RY1:A236G | c/c | 81 (74.8–85.7) | 0.03 | c/c vs c/g: 0.025 | 76 (71.6–81.6) | 0.019 | c/c vs c/g: 0.015 | 86 (82.8–88.1) | 0.093 |
c/g | 77.7 (71.4–80.8) | c/c vs g/g: 0.85 | 66.2 (52.3–74.2) | c/c vs g/g: 0.74 | 83.1 (71.7–86.5) | ||||
g/g | 85.2 (82.5–89.6) | c/g vs g/g: > 0.99 | 71.1 (54.7–80.8) | c/g vs g/g: > 0.99 | 84.8 (77.1–87.3) | ||||
P2RY12:V34I | g/g | 72.9 (63.1–80.3) | 0.034 | g/g vs g/a: 0.96 | 66 (53.2–74.1) | 0.019 | g/g vs g/a: 0.36 | 82.5 (75.4–87.4) | 0.35 |
g/a | 77.7 (71.4–80.8) | g/g vs a/a: 0.031 | 72 (64.8–76.3) | g/g vs a/a: 0.024 | 83.8 (78.5–86.4) | ||||
a/a | 85.2 (82.5–89.6) | g/a vs a/a: 0.13 | 81 (79–86.5) | g/a vs a/a: 0.21 | 85.6 (85.6–92.3) | ||||
CYP2C41:H231R | g/g | 74.8 (69.5-78.3) | 0.28 | 68.3 (60.2 - 71.6) | 0.49 | 84.6 (82.1 - 85.6) | 0.38 | ||
a/g | 73.8 (61.7–80.9) | 70 (55–75.8) | 81.2 (71.8–86.5) | ||||||
a/a | 80.3 (65.1 - 83.0) | 74.2 (60.1 - 80.4) | 84.4 (82.4 - 87.7) |
