Figure 3
From: Ibrutinib does not prevent kidney fibrosis following acute and chronic injury
Ibrutinib promotes rhabdomyolysis-induced renal fibrosis. (A) Design of the study. (B) Kaplan–Meier survival curves after glycerol injection in mice receiving ibrutinib (Ibru) or vehicle (Veh) from day 3. (C) Blood urea nitrogen (BUN) 20 days after glycerol injection. (D–G) Representatives images and quantification of Sirius Red (D), Fibronectin (E), F4/80 (F) and B220 (G) staining 20 days after glycerol injection in mice receiving ibrutinib (Ibru) or vehicle (Veh) from day 3. Values are expressed as mean ± SEM. * p < 0.05, compared with the vehicle group (Mann–Whitney test, n = 5–10 mice); ns, not significant.
