Figure 3 | Scientific Reports

Figure 3

From: Osteogenic differentiation of human mesenchymal stromal cells and fibroblasts differs depending on tissue origin and replicative senescence

Figure 3

ALK-3 expression in P3 versus culture senescence cells at P10. (A) Evaluated was the ALK-3 expression in DSC at P3. Expression of ALK-3 increased over the course of osteogenic differentiation. (B) Evaluated was the ALK-3 expression in DSC at P10. The ALK-3 was expressed at a small amount at P10. (C) Evaluated was the ALK-3 expression in ASC at P3. (D) Evaluated was the ALK-3 expression in ASC at P10. ALK-3 showed a minor expression. (E) Evaluated was the ALK-3 expression in FB at P3. The expression increased slightly on day 7 and 14, but decreased again at day 21. (F) Evaluated was the ALK-3 expression in FB at P10. Grey bars represent these cells incubated with osteogenic differentiation media supplemented with BMP-2. White bars represent cells differentiated with standard osteogenic differentiation media (OM). Bars represent mean ± SD of three donors.

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