Table 1 The probiotic-pathogen shared gene orthogroups (genetic niche overlap) that might rationalize the benefit or detriment of the probiotic to the pathogen.

From: Probiotics: their action against pathogens can be turned around

Strain

Copy number

Gene ontology [number]

Protein name [gene name]

Organism

[protein identity]

Lactip. plantarum strain L75a & V. parahaemolyticus strain 64

Single

Quorum sensing [0009372]

Autoinducer-2 production protein LuxS [luxS]

Lactip. plantarum ATCC BAA-793 [100%], V. parahaemolyticus O3:K6 strain RIMD 2210633 [99.419%]

Multiple

–

–

–

Lactip. plantarum strain L75a, V. parahaemolyticus strain 64, 191 LAB & 225 Vibrionaceae reference strains

Single

–

–

–

Multiple

–

–

–

  1. Genome sequences of 191 LAB and 225 Vibrionaceae strains with complete genome level as indicated in NCBI database website, including all Lactip. plantarum, Lactococcus lactis, Lacto. garvieae, Weissella hellenica, Pediococcus pentosaceus, Leuconostoc pseudomesenteroides, V. parahaemolyticus, V. harveyi, V. campbellii, V. rotiferianus, V. alginolyticus, V. cholerae, V. anguillarum, V. vulnificus and Photobacterium damselae, were downloaded from RefSeq database18 and used as reference sequences. After orthogroup inference, functional gene annotation, and preclusion of those related to regular basic biological processes, the sole remaining shared gene orthogroup possessed by both Lactiplantibacillus17 and Vibrio is related to quorum sensing. ‘–’ indicates not available. Shared gene orthogroups with protein identity lower than 90% are not shown.
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