Table 1 Demographic information for study cohort.

From: Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety

 

Combined

Females

Males

p value

Infant characteristics

N

52

28

24

 

Gestation length (weeks)

39.81 (1.16)

39.79 (1.13)

39.84 (1.23)

0.88

Birth weight (kg)

3.59 (0.51)

3.54 (0.52)

3.64 (0.51)

0.5

Birth length (cm)

52.07 (2.58)

51.77 (2.58)

52.46 (2.59)

0.36

Birth head circumference (cm)

34.81 (1.38)

34.45 (1.21)

35.29 (1.47)

0.05

5 min APGAR score

8.92 (0.34)

8.89 (0.42)

8.95 (0.21)

0.48

Gestation corrected age at MRI (days)

32.79 [19–50]

32.46 [19–50]

33.17 [22–42]

0.69

Maternal characteristics

Age at birth (years)

32.87 (4.13)

33.33 (3.69)

32.32 (4.60)

0.39

Years of education

32.87 (4.14)

17.50 (2.57)

17.58 (2.57)

0.91

Family income

 $30,001–50,000

7 (13.5%)

4 (14.3%)

3 (12.5%)

0.04

 $50,001–100,000

22 (42.3%)

7 (25.0%)

15 (62.5%)

 

 $100,001–200,000

22 (42.3%)

16 (57.1%)

6 (25.0%)

 

 Not reported/missing

1 (1.9%)

1 (3.6%)

0 (0%)

 

Marital status

 Married

46 (88.5%)

24 (85.7%)

22 (91.7%)

0.52

 Single

2 (3.8%)

1 (3.6%)

1 (4.2%)

 

 Divorced/separated

2 (3.8%)

1 (3.6%)

2 (8.3)%

 

 Not reported/missing

2 (3.8%)

2 (7.1%)

0 (0%)

 

Race

 African  American/Black

2 (3.8%)

2 (7.1%)

0 (0%)

0.33

 Asian

2 (3.8%)

1 (3.6%)

1 (4.2%)

 

 Caucasian/White

44 (84.6%)

22 (78.6%)

22 (91.7%)

 

 Native Hawaiian or other Pacific Islander

2 (3.8%)

2 (7.1%)

0 (0%)

 

 Mixed race

1 (1.9%)

1 (3.6%)

0 (0%)

 

 Not reported/missing

1 (1.9%)

0 (0%)

1 (4.2%)

 

Medication status

 Antidepressants

6 (11.5%)

1 (3.6%)

5 (20.8%)

0.13

 Corticosteroids

2 (3.8%)

2 (7.1%)

0 (0%)

 

 Hormones

2 (3.8%)

2 (7.1%)

0 (0%)

 

 Pain relief or nonsteroidal

13 (25.0%)

6 (21.4%)

7 (29.2%)

 

 None

32 (61.5%)

18 (64.3%)

14 (58.3%)

 

Alcohol use during pregnancy

19 (36.5%)

10 (35.7%)

9 (37.5%)

0.9

Tobacco use during pregnancy

1 (1.9%)

0 (0%)

1 (4.2%)

0.28

Delivery method

 Vaginal

37 (71.2%)

20 (71.4%)

17 (70.8%)

0.12

 Cesarean section

12 (23.1%)

8 (28.6%)

4 (16.7%)

 

 Not reported/missing

3 (5.8%)

0 (0%)

3 (12.5%)

 

Edinburgh Postnatal Depression Scale

 28 week

7.24 (4.74)

6.42 (4.25)

8.13 (5.17)

0.21

 35 week

6.34 (4.07)

5.36 (3.78)

7.50 (4.17)

0.06

State Trait Anxiety Index

 28 Week

11.62 (6.95)

10.54 (6.67)

12.79 (7.20)

0.26

 35 Week

12.25 (5.69)

10.71 (4.58)

14.04 (6.40)

0.04

Depression/anxiety composite score

1.99 (9.28)

-0.23 (7.98)

4.57 (10.15)

0.07

Hours between birth and cord blood processing

15.6 (24.0)

21.7 (33.0)

9.8 (7.5)

0.16

  1. Data are presented as mean (standard deviation) or number (percentage), as indicated. P values correspond to comparisons between males and females using T-tests or Chi-squared tests, where appropriate.