Table 1 IC50 for P1 and P3 acting on cancer cells in the apo- and holo-forms.

From: Copper-binding anticancer peptides from the piscidin family: an expanded mechanism that encompasses physical and chemical bilayer disruption

IC50 (µmol/L)

HT1080

MDA-MB-231

A549

HeLa

P1

5.58a (5.41–5.77)

5.83b (4.82–7.04)

4.20a (3.71–4.65)

2.22a (1.37–3.61)

P1-Cu2+

5.31 (4.91–5.75)

3.92b (3.54–4.33)

2.15 (1.94–2.30)

2.17 (1.32–3.60)

P3

26.01 (23.7–28.6)

17.5b (11.8–26.0)

21.6 (20.4–23.7)

18.1b (10.8–30.4)

P3-Cu2+

5.52 (5.03–6.05)

5.25b (4.32–6.37)

2.99 (2.60–3.34)

1.97 (1.24–3.12)

  1. The range of concentrations corresponding to the 95% confidence interval are provided in parentheses.
  2. aFrom this work. Comparison to data in Lin et al.39 is provided in the text.
  3. bFirst data point at 0.16 µmol/L was not used to extract IC50 values due to large deviation from the trend line but all data points are displayed in Fig. 1.
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