Figure 2

Proposed algorithm for Whipple disease in patients in whom rheumatism is suspected. CSF cerebro-spinal fluid, CWD classic Whipple disease, PAS periodic acid-Schiff, SB small bowel, WD Whipple disease. Cases of spondylodiscitis not considered in this algorithm. **Discuss CSF PCR in case of neurologic symptoms. *In case of chronic arthritis with negative synovial fluid PCR, discuss synovial biopsy. NB Data on cutaneous biopsy PCR were to scarce in our cohort integrate it on the algorithm.