Figure 3
From: Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice
Reduced anxiety of GPer2 and vGPer2 animals in the elevated O-maze. (A) Time spent in the open area of the O-maze is longer in GPer2 (GCre+ Per2fl/fl, red) animals compared to controls (blue) (n = 16 and 18, respectively, two-tailed t-test, *P < 0.05). (B) Time spent in the open area of the O-maze is significantly longer in vGPer2 (AAV-PHP.eB Gfap-iCre, green) compared to controls (blue) (n = 6 and 7, respectively, two-tailed t-test, *P < 0.05). (C) Entries into the open section of the O-maze are not significantly different between the GPer2 animals (red) and their controls (blue) (n = 16 and 18, respectively, two-tailed t-test, P = 0.15). (D) The number of entries into the open section of the O-maze is higher in vGPer2 animals (green) compared to their controls (blue) (n = 6 and 7, respectively, two-tailed t-test, *P < 0.05).
