Figure 10
Genes and pathways whose deletion strains were affected by formaldehyde and 4NQO. Formaldehyde sensitized strains lacking CDC26, RAD5 and RAD18 which are involved in DNA repair process. Similarly, 4NQO induced sensitivity for strains deleted for RAD2, RAD14, RAD10, MMS2 and MUS81, involved in DNA repair. As can be seen from the figure, many affected genes are those involved in cell cycle and DNA repair. Not all pathways at significant FD score are shown, e.g. chromatin remodelling in 4NQO. Plots were generated using the Bioconductor program v3.12, https://www.bioconductor.org/.
