Scientific Reports

Table 1 An overview of major genes and their pathways (by nature of their deletion strains) affected by each of the 10 compounds screened.

From: A genome-wide portrait of pervasive drug contaminants

Pathway	NDMA	NDEA	NMBA	DMF	Methylamine	Ethylamine	Formamide	NH₄SO₄	Formaldehyde	4NQO
ARGININE biosynthesis	ARG3, ARG1, ORT1, ARG5,6 CPA1, ARG4, CPA2, ARG2, ARG7	ARG3, ARG5,6, ARG1, ORT1, CPA1, CPA2		ARG3, ARG5,6, ARG1, ORT1, ARG4, CPA2, CPA1, ARG2, ARG7	ARG3, ARG1, ARG4, ARG5,6, ORT1, ARG2	ARG3	ARG3, CPA2, CPA1, ARG1, ORT1	ARG3
Other amino acid metabolism	GCN4, PRO1	TRP3, TRP4, TRP1, TRP5, GCN4, HOM6, CYS4, CYS3	ILV1	GCN4	GCN4	THR1, HOM2	GCN4, ORT1, ARO2, CYS4	THR1, HOM3, HOM2, HOM6, THR4		THR1
Other amino acid metabolism	GCN4, PRO1	TRP3, TRP4, TRP1, TRP5, GCN4, HOM6, CYS4, CYS3	ILV1	GCN4	GCN4	THR1, HOM2	GCN4, ORT1, ARO2, CYS4	SER2, SER1, ALT1		THR1
Chromatin remodeling	NPL6	NPL6, SNF5			YAF9, SNF6, SNF5, SNF2, SWC5, HTL1, SWR1, VPS71	SNF6, RSC2, SNF5	HTZ1, HTL1, YAF9, ARP6, SWC3, SWR1, VPS7, SWC5	SNF5		SNF2, ARP8, NPL6, ARP5, IES6, SNF5,, ARP6,
DNA repair and cell cycle or cell morphogenesis	RAD5, RAD18	RAD5, RAD18, RAD55, RAD57	ELM1, SRV2						SRS2, RAD18, RAD51, RAD55, RAD27, RRD1, MUS81	RAD2, RAD14, RAD7, RAD5, REV1
DNA repair and cell cycle or cell morphogenesis	RAD5, RAD18	RAD5, RAD18, RAD55, RAD57	ELM1, SRV2						CDC26, SWM1	DBF2, RAD9, PAT1
ATP export protein targeting to vacuole	VPS8, VPS45, VPS16, VPS9, VPS27, VPS36	VPS27, VPS28, VPS20, DID4, VPS2, SNF8, VPS36, SNF7, VPS24, STP22	SNF8, VPS36, VPS28, VPS27, STP22, VPS25, VPS8, VPS63, VPS16	VPS25, VPS36, STP22, VPS28, SNF8, VPS27, VPS20, DID4, BRO1, SNF7	VPS16, VPS41, CCZ1, MON1, VPS33, VPS71, VID24, STP22, APM3		VPS20, VPS28, SNF7, VPS36, SNF8, STP22, VPS25, DOA4	VPS45, VPS16, VPS1, APL6, APM3, VPS41, APS3	VPS8, VPS16	VPS9, VPS8, VPS45, SNF8, VPS64, STP22, VPS28, SNF7, VPS25
Fatty acid biosynthetic process	OAR1, MCT1, PPT2, HTD2, ETR1, HFA1, CEM1			MCT1, ELO3, PPT2, HTD2, CEM1
Protein lipoylation or protein urmylation	LIP5, LIP2, AIM22, GCV3	ELP6, ELP2, UBA4, URM1, NCS6, NCS2		LIP5, GCV3, AIM22, LIP2
Iron–sulphur cluster	ISA1, ISA2, IBA57	ISA1, ISA2, IBA57		ISA1, ISA2, IBA57
Mitochondrial genome maintenance & translation	GGC1, MDJ1, MDM10, HMI1, GEP5, MEF2, RSM27, IMG1, RSM19, NAM2	MDJ1, MDM12, MDM34, HMI1, GGC1, MEF2, MRPL32, MRP7

The comprehensive data can be individually assessed through the Chemogenomic Web Application https://ggshiny.shinyapps.io/2020NitrosoMechanisms/.

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