Figure 2 | Scientific Reports

Figure 2

From: Cholesterol-dependent transcriptome remodeling reveals new insight into the contribution of cholesterol to Mycobacterium tuberculosis pathogenesis

Figure 2

Differential gene expression of cholesterol import and breakdown genes. DGE analysis was performed comparing conditions of Mtb grown in glycerol vs cholesterol (CHOL) or glycerol vs 7H9/10% OADC medium (RICH). The results are presented as a heatmap of the log2-fold change in expression. See the color key for log2FC values. (A) Gene expression within KstR1, KstR2, MceR, and SigE regulon genes that were previously assigned as cholesterol-induced/associated. Genes that belong to the Cho-region9 are marked dark blue (B) DGE analysis of a functional compilation of genes that were previously classified in various studies28 as induced by cholesterol and involved in cholesterol import and breakdown.

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