Figure 4 | Scientific Reports

Figure 4

From: Cholesterol-dependent transcriptome remodeling reveals new insight into the contribution of cholesterol to Mycobacterium tuberculosis pathogenesis

Figure 4

Transcriptional response of Mtb intermediary metabolism in channeling cholesterol degradation metabolites when cholesterol is utilized as a sole carbon source. DGE analysis of the main pathways of acetyl-CoA, propionyl-CoA, and pyruvate amelioration in Mtb and ∆prpR mutant. The two datasets represent DGE analysis comparing growth in glycerol vs cholesterol of the Mtb wild-type strain (W) and ΔprpR mutant (∆). Transcriptional changes that were not cholesterol-specific (were present also in standard 7H9/10% OADC medium) were excluded from the analysis. See the color key for log2FC values. TCA tricarboxylic acid cycle, GC glyoxylate cycle, MCC methylcitrate cycle, MMP methylmalonyl pathway. Up-regulated and down-regulated pathways are shown in red and blue, respectively.

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