Table 2 Pectoralis major fiber size and cellular parameters in control and mesterolone-treated groups.

From: Differential response of oxidative and glycolytic skeletal muscle fibers to mesterolone

Parameter

Control

M1

M2

M3

M4

Fiber CSA (µm2)

2042 ± 244

2616 ± 267**

2718 ± 186**

2390 ± 22*

2631 ± 133**

Lesser fiber diameter (µm)

42.2 ± 2.4

48.3 ± 2.4**

48.4 ± 2.1**

46.9 ± 1.2*

46.8 ± 1.1*

SCs per 100 fibers

8.0 ± 1.0

20.3 ± 4.8**

16.5 ± 3.4*

20.7 ± 4.6**

15.5 ± 4.5*

SCs per 1 mm

3.9 ± 0.4

10.0 ± 2.4**

8.1 ± 1.7*

10.2 ± 2.3**

7.6 ± 2.2*

SC frequency (%)

3.3 ± 0.3

6.3 ± 1.3**

5.0 ± 0.7*

6.0 ± 1.0**

4.8 ± 1.3*

Surface area of plasmalemma per SC (µm2)

144,936 ± 22,869

67,980 ± 18,521**

81,927 ± 14,250**

63,640 ± 11,869**

86,245 ± 19,336**

MN per 100 fibers

235.8 ± 14.3

300.5 ± 25.4**

313 ± 22.1**

321.3 ± 22.9**

309.8 ± 10.7**

MN per 1 mm

114.5 ± 6.9

146.0 ± 12.3**

152.1 ± 10.8**

156.1 ± 11.1**

150.6 ± 5.2**

MND (µm3)

17,930 ± 2951

17,998 ± 2170

17,904 ± 1244

15,382 ± 1077

17,488 ± 1076

  1. M1, M2, M3, M4: groups treated with 4, 8, 12, and 16 mg/kg mesterolone, respectively. CSA: cross-sectional area; SC: satellite cell; MN: myonuclei; MND: myonuclear domain. Values represent the means ± standard deviations. *P < 0.05, **P < 0.01 significantly different from the control group (ANOVA, LSD post-hoc).
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