Figure 6
Histopathology findings of lung and kidney in COVID19 patients and controls. Representative H&E and TUNEL staining in (a) lung and (b) kidney tisuses from patients with COVI19 (COVID-19, n = 9) and controls (Control, n = 5). Black arrows indicate mononuclear inflammatory cells. Lung injury was assessed on a scale of 0–2 for each of the following criteria: (i) alveolar polymorphonuclear neutrophils, (ii) chronic alveolar inflammation/macrophages, (iii) acute alveolar wall Inflammation, (iv) chronic alveolar wall inflammation, (v) hyaline membranes, (vi) Type 2 hyperplasia only, (vii) Type 2 hyperplasia with fibroblasts, and (viii) organizing pneumonia and squamous metaplasia. The final injury score was derived from the following calculation: Score = I + ii + iii + iv + v + vi + vii + viii. G indicates glomerulus. Banff Score: g, glomerulitis; i, interstitial inflammation; ptc, peritubular capillaritis; ct, tubular atrophy; ci, interstitial fibrosis; cv, vascular fibrous intimal thickening; ti, total inflammation. *p < 0.05, **p < 0.01.
