Table 3 Association between life-course trajectories of weight categories and cumulative incidence of type 2 diabetes.

From: Life-course trajectories of weight and their impact on the incidence of type 2 diabetes

Risk ratios (RR)

Women

Men

Unadjusted

RR (95% CI)

Adjusted

RR (95% CI)

Unadjusted

RR (95% CI)

Adjusted

RR (95% CI)

Stable normal weight

1 (ref)

1 (ref)

1 (ref)

1 (ref)

Stable overweight

3.69 (2.76–4.95)

2.77 (2.06–3.72)

2.94 (2.12–4.08)

2.68 (1.92–3.75)

Lean increasing weight

1.98 (1.50–2.60)

1.71 (1.31–2.24)

1.32 (0.96–1.81)

1.35 (0.98–1.85)

Overweight from early adulthood

4.07 (3.25–5.11)

3.43 (2.72–4.34)

3.03 (2.40–3.84)

2.77 (2.17–3.37)

Overweight from late adulthood

2.78 (2.13–3.63)

2.27 (1.75–2.95)

1.76 (1.29–2.40)

1.73 (1.26–2.37)

Absolute risk difference (ARD)

Unadjusted

ARD% (95% CI)

Adjusted

ARD% (95% CI)

Unadjusted

ARD% (95% CI)

Adjusted

ARD% (95% CI)

Stable normal weight

0 (ref)

0 (ref)

0 (ref)

0 (ref)

Stable overweight

10.90% (6.97%-14.83%)

7.94% (4.65%-11.24%)

15.05% (7.89%-22.21%)

13.11% (6.23%-19.99%)

Lean increasing weight

3.35% (1.34%-5.27%)

2.46% (0.57%-4.36%)

3.92% (0.05%-7.36%)

4.61% (0.95%-8.28%)

Overweight from early adulthood

9.03% (6.63%-11.40%)

7.76% (5.36%-10.17%)

15.23% (11.52%-18.95%)

14.05% (10.30%-17.79%)

Overweight from late adulthood

5.02% (2.66%-7.38%)

3.512% (1.36%-5.68%

4.84% (0.85%-8.82%)

5.23% (1.03%-9.43%)

  1. Models for males and females were estimated separately. Covariates included in the adjusted model for were age, family history of type 2 diabetes, general health, comorbidities, self-reported physical activity, smoking, and alcohol consumption for both sexes and history of gestational diabetes for women. Adjusted absolute risk differences were estimated using the mean of all covariates.