Table 2 Mean difference to human and p-values of the gene expression calculated with ANOVA of healthy, transiently inflamed and constantly inflamed tenocytes of the four animal model species.

From: Species variations in tenocytes’ response to inflammation require careful selection of animal models for tendon research

			SCX	TNC	TNM	COL1	COL3	COL5	MMP1	MMP3	MMP13	IL6	COX2	NFKB	P53	ALP	FAK
Healthy	Mouse	Diff	2.65	− 0.74	− 1.05	− 3.03	2.54	− 2.17	− 9.34	9.45	8.50	4.65	9.40	− 0.20	− 0.30	3.14	− 0.25
	Mouse	Adj p	0.230	0.811	0.951	0.038	0.122	0.609	0.064	0.002	0.000	0.005	0.000	0.999	0.961	0.032	0.995
	Rat	Diff	5.28	2.84	− 1.37	3.95	3.80	4.62	− 2.97	10.24	5.24	0.54	11.30	3.00	4.47	1.85	4.72
	Rat	Adj p	0.008	0.014	0.882	0.008	0.015	0.067	0.851	0.001	0.013	0.978	0.000	0.053	0.000	0.287	0.000
	Sheep	Diff	2.39	3.79	− 3.52	− 7.91	− 0.50	0.41	− 4.71	9.12	9.47	− 0.16	13.61	− 0.72	− 0.36	− 0.14	3.95
	Sheep	Adj p	0.313	0.002	0.201	0.000	0.981	0.998	0.539	0.003	0.000	1.000	0.000	0.931	0.927	1.000	0.001
	Horse	Diff	1.49	− 0.24	− 3.11	− 4.72	0.41	1.71	− 2.93	1.94	5.37	− 3.67	15.65	3.79	3.52	− 1.11	2.11
	Horse	Adj p	0.711	0.996	0.296	0.002	0.991	0.780	0.857	0.793	0.012	0.022	0.000	0.014	0.000	0.720	0.055
Transient inflammation	Mouse	Diff	− 1.22	− 0.69	− 2.59	− 2.62	− 3.06	− 3.07	1.23	− 5.08	− 4.96	− 4.02	− 4.15	− 1.24	− 0.59	0.46	− 0.46
	Mouse	Adj p	0.515	0.870	0.048	0.177	0.017	0.010	0.984	0.011	0.001	0.001	0.000	0.180	0.803	0.990	0.963
	Rat	Diff	− 2.94	− 1.42	− 2.85	− 2.93	− 4.43	− 3.57	− 0.66	− 3.22	− 1.56	− 0.98	− 4.84	− 0.01	− 0.34	− 1.54	− 1.48
	Rat	Adj p	0.019	0.342	0.029	0.114	0.001	0.004	0.999	0.124	0.412	0.537	0.000	1.000	0.967	0.563	0.299
	Sheep	Diff	− 0.59	− 0.20	0.59	− 0.12	− 1.84	− 1.49	0.39	− 6.54	− 4.19	− 2.83	− 6.20	− 0.52	0.16	1.38	1.31
	Sheep	Adj p	0.930	0.998	0.937	1.000	0.189	0.291	1.000	0.002	0.004	0.007	0.000	0.841	0.998	0.651	0.404
	Horse	Diff	− 0.77	1.44	− 0.34	1.40	− 0.36	− 0.95	3.97	− 0.32	0.15	3.25	− 6.63	− 0.16	1.38	2.22	0.98
	Horse	Adj p	0.840	0.330	0.992	0.691	0.989	0.671	0.498	0.999	1.000	0.003	0.000	0.997	0.152	0.249	0.658
Constant inflammation	Mouse	Diff	− 1.23	− 0.51	− 3.33	− 1.89	− 3.30	− 2.52	1.64	− 4.82	− 3.41	− 4.54	− 3.96	− 1.33	− 0.09	2.83	0.22
	Mouse	Adj p	0.911	0.949	0.166	0.361	0.003	0.501	0.977	0.014	0.209	0.021	0.094	0.586	1.000	0.093	0.998
	Rat	Diff	− 3.27	− 1.76	− 4.86	− 3.80	− 7.16	− 5.29	4.75	− 1.96	3.26	1.13	− 1.71	0.13	0.18	− 1.09	− 1.35
	Rat	Adj p	0.238	0.177	0.028	0.020	0.000	0.039	0.509	0.490	0.241	0.866	0.727	1.000	0.999	0.797	0.412
	Sheep	Diff	− 2.01	− 0.63	− 1.41	0.56	− 1.81	− 2.94	1.51	− 6.73	− 2.93	− 0.42	− 7.68	− 0.18	0.19	1.24	1.48
	Sheep	Adj p	0.653	0.900	0.822	0.975	0.111	0.366	0.983	0.001	0.328	0.996	0.002	1.000	0.999	0.719	0.333
	Horse	Diff	− 3.10	2.28	− 1.74	1.37	− 0.39	− 2.04	3.59	− 0.24	1.49	5.53	− 8.36	− 0.63	0.95	3.18	0.58
	Horse	Adj p	0.280	0.059	0.693	0.637	0.972	0.679	0.733	1.000	0.839	0.006	0.001	0.949	0.678	0.054	0.932

Significant p-values (Tukey HSD correction, p<0.05) and the matching mean differences in gene expression to humans are indicated in bold.

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Table 2 Mean difference to human and p-values of the gene expression calculated with ANOVA of healthy, transiently inflamed and constantly inflamed tenocytes of the four animal model species.

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