Figure 5
From: Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG
The BCGΔBCG1419c vaccine candidate is more effective than BCG in reducing extrapulmonary TB in guinea pigs. (a) Bacterial replication in spleens of guinea pigs (n = 5 in saline and BCG groups, n = 10 in the BCGΔBCG1419c group) at 40 days post-infection. Mean Log10 CFU with SD are shown, including individual data. A Kruskal–Wallis test followed by Dunn’s multiple comparison was used to compare M. tuberculosis burden and significant p values are shown. Lesions were evaluated using a scoring system to compare (b) Lesion severity in spleens. (c) Extent of lesions in spleens. (d) Total spleen score. (e) Lesion severity in livers. (f) Total liver score. Data (n = 4–10, depending on groups) are presented as a box and whisker plot showing all points. Categorized data were analyzed with a H Kruskal–Wallis test using SPSS version 25 (α = 0.05). In all cases, p value was adjusted for multiple comparisons with Bonferroni correction.
