Table 1 Clinical characteristics according to age.

From: Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2

 

Total (N = 1010)

Age (years)

P value

 < 70 (N = 303)

 ≥ 70 to < 80 (N = 337)

 ≥ 80 (N = 370)

Age, median (IQR), y

76 (68–82)

64 (55–67)

75 (73–77)

85 (82–87)

< 0.0001

Male sex, No. (%)

603 (60%)

226 (75%)

219 (65%)

158 (43%)

< 0.0001

Hypertension, No. (%)

584 (58%)

140 (46%)

204 (61%)

240 (64%)

< 0.0001

Diabetes mellitus, No. (%)

193 (19%)

63 (21%)

71 (21%)

69 (16%)

0.15

Atrial fibrillation, No. (%)

533 (53%)

119 (39%)

182 (54%)

232 (63%)

< 0.0001

Pre-stroke mRS score ≥ 2, No. (%)

897 (89%)

291 (96%)

310 (92%)

296 (80%)

< 0.0001

NIHSS score, median (IQR)

18 (13–23)

16 (12–22)

18 (13–23)

18 (14–23)

0.0021

Blood glucose, median (IQR), mg/mL (N = 984)

128 (110–156)

126 (111–156)

129 (110–156)

127 (110–154)

0.98

Systolic blood pressure, median (IQR), mmHg (N = 981)

154 (135–170)

150 (128–167)

152 (136–170)

160 (140–173)

< 0.0001

Location of occlusion

ICA, No. (%)

346 (34%)

89 (29%)

123 (36%)

134 (36%)

0.101

M1 segment MCA, No. (%)

424 (42%)

129 (43%)

140 (42%)

155 (42%)

0.97

M2 segment MCA, No. (%)

177 (18%)

62 (20%)

50 (15%)

65 (18%)

0.17

M3 segment MCA, No. (%)

6 (1%)

3 (1%)

2 (1%)

1 (0%)

0.48

A1 segment ACA, No. (%)

3 (0%)

0 (0%)

2 (1%)

1 (0%)

0.38

A2 segment ACA, No. (%)

12 (1%)

3 (1%)

4 (1%)

5 (1%)

0.91

BA, No. (%)

177 (8%)

27 (9%)

29 (9%)

21 (6%)

0.21

VA, No. (%)

8 (1%)

6 (2%)

1 (0%)

1 (0%)

0.020

P1 segment PCA, No. (%)

5 (0%)

3 (1%)

0 (0%)

1 (0%)

0.044

P2 segment PCA, No. (%)

2 (0%)

0 (0%)

1 (0%)

1 (0%)

0.65

IV-rtPA therapy, No. (%)

482 (48%)

158 (52%)

163 (48%)

161 (44%)

0.080

ASPECTS on CT, median (IQR) (N = 638)

10 (7–10)

10 (8–10)

10 (8–10)

10 (8–10)

0.82

ASPECTS on DWI, median (IQR) (N = 788)

7 (6–8)

7 (6–8)

8 (6–9)

7 (6–9)

0.12

pc-ASPECTS, median (IQR) (N = 80)

7 (6–8)

7 (6–8)

7 (6–8)

7 (6–8)

0.98

ASPECTSa ≥ 6, No. (%)

843 (83%)

250 (83%)

27 (82%)

317 (86%)

0.35

Onset-to-puncture time, median (IQR), minutes

205 (135–355)

205 (135–320)

200 (135–345)

215 (140–400)

0.11

Onset-to-reperfusion time, median (IQR), minutes

270 (195–435)

265 (185–385)

260 (185–410)

280 (205–475)

0.060

  1. ACA anterior cerebral artery, ASPECTS Alberta Stroke Program Early Computed Tomography Score, BA basilar artery, CT computed tomography, DWI diffusion-weighted imaging, ICA internal carotid artery, IV-rtPA intravenous recombinant tissue plasminogen activator, IQR interquartile range, MCA middle cerebral artery, mRS modified Rankin Scale, NIHSS National Institutes of Health Stroke Scale, PCA posterior cerebral artery, VA vertebral artery.
  2. aASPECTS was derived from CT or DWI. If both CT and DWI were performed before endovascular therapy, ASPECTS on DWI was used for the analysis. In patients with stroke in the posterior circulation, posterior circulation ASPECTS on DWI was used for the analysis.
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