Figure 4

Relationship between mutational signature and the IPM. (A) Stacked plots of mutational frequency in individual tumors (histogram, top), mutations in the top 20 genes (tile plot, middle), their mutational counts (histogram, right) and mutational types (bottom). (B) GSEA enrichment plots of immune-related phenotype in low TMB patients compared with that in high TMB patients. (C) Correlation analyses between survival time and risk score based on TMB level. (D) Risk score distribution in high- and low-TMB groups. Data are presented as mean ± SEM. (E) Kaplan–Meier curves showing favorable survival in patients with high TMB. (F) Kaplan–Meier curves showing significantly prolonged survival in patients with high TMB and low risk compared with patients with low TMB and high risk.