Table 1 Association between the AK5 expression and clinicopathologic factors.

From: Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma

Characteristic

No. (n = 615)

AK5 expression

Low (%)

High (%)

P-value

(n = 273)

(n = 342)

Age (yr)

≤ 60

215

101

114

0.344

> 60

400

172

228

 

Gender

Male

359

162

197

0.664

Female

256

111

145

 

Location

Colon

369

159

210

0.426

Rectum

246

114

132

 

Differentiation

Well

249

94

155

0.026†

Moderate

358

172

186

 

Poor

8

7

1

 

Size

≤ 6 cm

484

211

273

0.446

> 6 cm

131

62

69

 

pT stage

pTis, pT1, pT2

145

63

82

0.794

pT3, pT4

470

210

260

 

LVI

Absent

522

226

296

0.195

Present

93

47

46

 

PNI

Absent

575

261

314

0.058

Present

40

12

28

 

LN metastasis

Absent

375

173

202

0.277

Present

240

100

140

 

AJCC stage

Stage 1, 2

353

161

192

0.480

Stage 3, 4

262

112

150

 

Distant metastasis

Absent

540

239

301

0.861

Present

75

34

41

 

RM

Negative

608

270

338

0.935

Positive

7

3

4

 

Local recur

Absent

590

263

327

0.652

Present

25

10

15

 
  1. AJCC American Joint Committee on Cancer, LVI lymphovascular invasion, PNI perineural invasion, LN lymph node, RM resection margin. †P-values < 0.05 were considered statistically significant.
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