Table 1 Imaging and blood-based factors, our outcomes of interest, and our exploratory cognitive measures.

From: A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise

 

Brain imaging and physiologic factors

Proposed blood-based factors to be analyzed

Cognition

Outcomes of Interest

(1) Global CBF, area under the post-exercise recovery curve

(1) BDNF

(2) IGF11

(3) VEGF

[Change in platelet-free plasma concentrations]

(1) Episodic Memory [Picture Sequence Memory Test]

(2) Processing Speed [Pattern Comparison Test]

(3) Attention and Executive Function [Flanker Inhibitory Control and Attention Test]

Ancillary physiological, grouping, and experimental variables of interest

(1) Brain anatomy, acquired pre-exercise

(2) Blood Pressure

(3) Heart rate

(4) Workload

(1) APOE genotype

 
  1. APOE apolipoprotein e, CBF cerebral blood flow, BDNF brain derived neurotrophic factor, VEGF vascular endothelia growth factor, IGF1 Insulin-like growth factor 1.
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