Table 1 PXVX0200 viability when reconstituted in US and EU tap waters (2018).

From: CVD 103-HgR live, attenuated cholera vaccine strain viability in drinking waters from the US and Europe

Source

Arithmetic mean CFU/dose post reconstitution

T0

15 min

30 min

Miamia

6.24 × 108

6.65 × 108

5.82 × 108

San Diego

1.59 × 108 ± 1.07 × 107

BLQb

BLQ

Redwood City

6.65 × 108 ± 4.24 × 106

7.88 × 108 ± 2.80 × 108

7.74 × 108 ± 3.76 × 108

Bern

7.99 × 108 ± 3.69 × 108

6.28 × 108 ± 3.60 × 108

5.53 × 108 ± 2.51 × 108

Londonc

1.03 × 109 ± 2.40 × 108

9.82 × 108

8.60 × 108 ± 1.51 × 108

Madrid

6.08 × 108 ± 3.81 × 108

5.50 × 108 ± 3.83 × 108

4.12 × 108 ± 4.26 × 108

Milan

1.10 × 109 ± 1.98 × 108

8.67 × 108 ± 1.69 × 108

8.30 × 108 ± 1.88 × 108

  1. Italicized values are below the PXVX0200 lower potency limit.
  2. aMiami sample was tested in singlicate due to availability of sample at the time of the study.
  3. bBLQ below level of quantification for the CFU assay.
  4. c15 min time-point for London sample is derived from a single measurement as the duplicate had no growth, which was attributed to a missed dilution during CFU sample preparation.
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