Figure 4
From: Protein residue network analysis reveals fundamental properties of the human coagulation factor VIII
Critical residues in FVIII. (a) Depicted are the degree and betweenness of all residues of the FVIII RIN, and their assignment to groups that reflect their centrality characteristics. Each dot is one residue from the RIN. (b) The location of the different groups of residues on the FVIII structure. Images created using the structure 2R7E (Ref.3) and Chimera 1.14 (Ref.62). (c) The relative surface exposure of the key residues identified using the FVIII RIN centrality measures. (d) The closeness of each residue of the FVIII RIN, colored according to the domain where they are located. (e) Boxplot summarizing the closeness centrality of the residues of each FVIII domain. The boxplots depict the median (center line), the first and third quartiles (lower- and upper-bounds), and 1.5 times the inter-quartile range (lower- and upper whiskers).
