Table 3 Results of the histological subtype-stratified meta-analysis of reported lung cancer variants in the Indian subcontinent.

From: A comprehensive meta-analysis and a case–control study give insights into genetic susceptibility of lung cancer and subgroups

   

Test for Association

Heterogeneity

Variant ID/ Gene

Histological subtypes

Number

Genetic Model

Comparison

Model

OR (95% CI); p-value†

I2

H2

phet§

del1/GSTT1

Squamous cell carcinoma

3

Recessive

Null (-/-) vs Present (+ /-, + / +)

Fixed

1.38 (0.7–2.74); 0.35

17.69

1.21

0.49

Adenocarcinoma

3

Fixed

2.14 (1.04–4.41); 0.04

0.79

1.01

0.91

Small Cell Lung Carcinoma

2

Fixed

1.15 (0.44–3.03); 0.77

26.08

1.36

0.31

del2/GSTM1

Squamous cell carcinoma

3

Recessive

Null (-/-) vs Present (+ /-, + / +)

Fixed

1.33 (0.74–2.4); 0.34

0.11

1

0.96

Adenocarcinoma

3

Fixed

1.32 (0.68–2.57); 0.41

24.23

1.32

0.48

Small Cell Lung Carcinoma

2

Fixed

1.53 (0.67–3.46); 0.31

0.32

1

0.77

rs4646903/CYP1A1

Squamous cell carcinoma

4

Dominant

(TC + CC) vs TT

Fixed

1.82 (1.06–3.11); 0.03

11.38

1.13

0.71

Adenocarcinoma

4

Fixed

1.36 (0.68–2.7); 0.38

20.93

1.26

0.6

Small Cell Lung Carcinoma

2

Fixed

0.88 (0.34–2.29); 0.8

0.001

1.02

0.98

rs1048943/CYP1A1

Squamous cell carcinoma

3

Dominant

(AG + GG) vs AA

Random

3.91 (1.49–10.19); 0.005

63.17

2.72

0.07

Adenocarcinoma

3

Fixed

3.38 (1.83–6.25); 0.0001

49.65

1.99

0.16

  1. †p-value < 0.05*, 0.01**, 0.001***, OR, Crude Odds Ratio, 95% CI, 95% Confidence Interval, I2 and H2 are measures of heterogeneity. §pHet < 0.1 (Cochran’s Q test). Significant associations are depicted in bold.
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